Metaheuristics for Drug Discovery
Implementation of metaheuristics applied to drug design for specific molecular targets.
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National University of Cuyo
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Gastón Dachary University
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Gastón Dachary University
Matías Gabriel Rojas
CONICET Doctoral Fellow • BSc in Computer Sciences
Mendoza City, Argentina
About
Bachelor of science in computer science. 31 years old. Doctoral Fellow at Consejo Nacional de Investigaciónes Científicas y Técnicas (CONICET), Argentina. Member of the Computing and Data Sciences Group at the Interdisciplinary Institute of Basic Sciences (ICB). My research focuses on the design and implementation of computational intelligence algorithms applied to bioinformatics problems.
Interests
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Differential Expression Analysis in Cancer
Biomarker discovery and differential gene expression analysis in cancer.
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Artificial Genetic Sample Production
Use of generative techniques for producing artificial gene expression samples.
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Alternative Neural Network Training for Medical Cases
Metaheuristics applied to the configuration of weights and biases in neural networks for medical diagnosis support.
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Multiple Sequence Alignment
Design of metaheuristics for the multiple alignment of DNA, RNA, and protein sequences.
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DNA Fragment Assembly and RNA Structure Design
Application of multi and single-objective metaheuristics for DNA fragment assembly and design of RNA molecules that fit specific folding structures.
Education
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Scientific publications
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2025
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Memetic genetic particle swarm optimization for druglike molecule discovery
IEEE Latin America Transactions • DOI: 10.1109/TLA.2025.10879174
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A new micro-genetic crossover operator for effective training of medical neural networks
Springer Nature Computer Sciences • DOI: 10.1007/s42979-025-04077-z
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Massive Production of Cancer Synthetic RNA-Seq Gene Expression Samples
Springer Nature Computer Sciences • DOI: 10.1007/s42979-025-04251-3
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Hibridación memética para el diseño de fármacos de-novo: una extensión al diseño de fármacos antidiabéticos
XXXII Jornadas de Jovenes Investigadores de la Asociación de Universidades Grupo Montevideo
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Desarrollo de metaheurísticas aplicadas a genómica estructural y funcional
Tercer Simposio Iberoamericano de Maestría y Doctorado en Inteligencia Artificial (SIMDIA’2025)
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Desarrollo de técnicas de inteligencia computacional y artificial aplicadas a problemas de genómica estructural y funcional
XXVII Workshop de Investigadores en Ciencias de la Computación, WICC 2025
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Diseño e implementación de metaheurísticas meméticas para la selección de genes relevantes en muestras de cáncer
Primeras Jornadas de Doctorado de la FCEN-UNCUYO
2024
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A genetic operators-based ant lion optimiser for training a medical multi-layer perceptron
Applied Soft Computing • DOI: 10.1016/j.asoc.2023.111192
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2023
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A Memetic micro-genetic algorithms for cancer data classification
Intelligent Systems with Applications • DOI: 10.1016/j.iswa.2022.200173
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2022
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Optimising multilayer perceptron weights and biases through a cellular genetic algorithm for medical data classification
Array • DOI: 10.1016/j.array.2022.100173
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Desarrollo de técnicas de inteligencia computacional para el análisis de datos genómicos
XXIV Workshop de Investigadores en Ciencias de la Computación, WICC 2022
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A modified multi-swarm optimization for weights and biases of a multi-layer perceptron for medical data classification
2022 IEEE Biennial Congress of Argentina, ARGENCON 2022 • DOI: 10.1109/ARGENCON55245.2022.9940066
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2020
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A memetic cellular genetic algorithm for cancer data microarray feature selection
IEEE Latin America Transactions • DOI: 10.1109/TLA.2020.9398628
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Hybrid cuckoo search for solving dna fragment assembly problem
4to Congreso Internacional de Ciencias de la Computación y Sistemas de Información
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Optimización de support vector machine mediante metaheurísticas para clasificación de retinopatía diabética
Jornadas Argentinas de Informática e Investigación Operativa, JAIIO 2020
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A memetic cellular genetic algorithm for multiple sequence alignment
2020 IEEE Biennial Congress of Argentina, ARGENCON 2020 • DOI: 10.1109/ARGENCON49523.2020.9505544
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Teaching experience
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Ad-honorem Teaching Assistant
National University of Cuyo
Subject: Compilers (4th Year)
Bachelor of Science in Computer Science • Facultad de Ingeniería
Computing | Area 22: Theory of Computation
Work experience
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IJS Ingeniería Eléctrica
Freelance PHP/Laravel Developer
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Ricardo Moya Consortium Management
Java Developer
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That Metal Shop
WordPress/WooCommerce Developer
Scholarships & grants
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Doctoral Research Fellowship
CONICET
Project: Design and development of metaheuristic techniques applied to bioinformatics problems
Advisor: Dra. Jessica Andrea Carballido | Co-Advisor: Dra. Ana Carolina Olivera
Interdisciplinary Institute of Basic Sciences (ICB), Mendoza
Postgraduate Course Scholarship 🇮🇹 International
University of Padua / Ministry of Education (AR)
Project: Advanced Bioinformatics Methods
Full scholarship covering travel expenses, transportation, and living allowance.
Padua, Italy
Research, Innovation, and Technological Development Scholarship
CEDIT
Project: Prototype of a web document classification system based on semantic relevance
Advisor: Ing. Fabián Edgardo Favrét
CITIC, Gastón Dachary University, Misiones
Research projects
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Intelligent methods used in image processing and their application in solving socio-productive problems
National University of Cuyo - SIIP Res. 1651/2025
Project Director: Dra. Ana Carolina Olivera | Co-director: Dr. Pablo Javier Vidal
ID: 80020240100021UN • Funding: $ 300,000 ARS
Development of algorithms, predictive modeling, and bioinformatic analysis based on the development of machine learning techniques
National University of the South - SGCyT Res. CSU-378/2025
Project Director: Dra. Jessica Andrea Carballido | Co-director: Dra. Rocio L. Cecchini
ID: 24/N061 • Funding: $ 1,450,964 ARS
Development of intelligent methods for early disease detection using digital images in problems transferable to the socio-productive sector
CONICET RD - EX-2022-90513226-APN-DCP#CONICET
Project Director: Dra. Ana Carolina Olivera | Co-director: Dr. Emmanuel Nicolás Millán
ID: PIP 2023-2025 • Funding: $ 2,950,000 ARS
Predictive modeling in bioinformatics based on the development of evolutionary computing and machine learning techniques
National University of the South - SGCyT Res. CSU-362/2020
Project Director: Dra. Jessica Andrea Carballido
ID: 24/N052 • Funding: $ 109,993 ARS
Computational intelligence applied to optimization problems
National University of Cuyo - SIIP Res. 3978/2022
Project Director: Dra. Ana Carolina Olivera | Co-director: Dr. Pablo Javier Vidal
ID: 06/B052-T1 • Funding: $ 80,000 ARS
Design and development of metaheuristic tools and novel applications oriented towards smart mobility
National University of Cuyo - SIIP Res. 4142/2019
Project Director: Dra. Ana Carolina Olivera | Co-director: Dr. Pablo Javier Vidal
ID: 06/B081-B • Funding: $ 22,500 ARS
Technical skills
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AI & Optimization
- Metaheuristics
- Machine Learning
- Deep Learning
Bioinformatics
- Drug Design
- Functional Genomics
- Structural Genomics
Development & Tools
- Python
- C++
- R
- LaTeX
- Git
- Astro
- Linux
Languages
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English
Advanced (C1)Green Hill Institute (in collaboration with EF)
Ability to understand complex texts for academic and research purposes.
Spanish
NativeNative language.